Nitrogen monoxide participation in the mechanisms of realization of the infarction-limiting effect of post-conditioning using lactate during myocardial ischemia-reperfusion in young and old rats

Cardiovascular diseases are the main cause of death and disability in economically developed countries world. Taking into account high medical, social, economic importance problem treating patients with coronary heart disease acute myocardial infarction, search for new effective methods how to prevent or weaken unfavorable effects ischemic reperfusion injury find out mechanisms their implementation is an urgent task modern experimental clinical medicine. The aim study was elucidate participation nitric oxide (NO) realization infarct-limiting effect post-conditioning (PostC) lactate during ischemia-reperfusion young old rats. According results, it found that PostC (10 mg/kg), carried at 25th minute after 30-minute occlusion, has infarction-limiting both However, animals under conditions systemic action inhibitor NO-synthase NG-nitro-L-arginine methyl ester a dose 25 mg/kg (intravenous administration 5 minutes before start 30 PostC), cardioprotective preserved only partially fully data obtained suggest activity NO level blood significant young, but not